It is an important salt of the thiocyanate anion, one of the pseudohalides. © 2021 American Medical Association. Magnesium helps regulate hundreds of body systems, including blood pressure, blood sugar, and muscle and nerve function. May cause psychosis, vomiting, disorientation, weakness, low blood pressure, convulsions and death which may be delayed. Recently, however, potassium thiocyanate has been hailed as the drug for reducing the blood pressure level. 1942;119(15):1177–1181. The effects of thiocyanate on basal and supplemental blood pressures. Potassium thiocyanate is a potassium salt which is the monopotassium salt of thiocyanic acid. 2019 Apr 2;14(4):e0214476. After four to ten days the potassium thiocyanate is given, if the necessary indications for its use are still present, in a dose of 2.1 g. weekly. A dose level of 100 mg/kg bw per day (sodium or potassium salt) caused a progressive loss of weight, apathy, head droop, ataxia, and ultimate death. It contains a thiocyanate. The iron(II) chloride should be rusty brown and the potassium thiocyanate should be white 3. Furthermore, the pharmaceutical industry uses thiocyanic acid as a raw material for antibiotics, chemotherapeutic drugs, and thyroid medications. 3. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/, NLM Please enable it to take advantage of the complete set of features! When it comes to fighting high blood pressure, the average American diet delivers too much sodium and too little potassium. Potassium thiocyanate in the treatment of hypertension. 1951 Apr 14;1(4710):778-84. doi: 10.1136/bmj.1.4710.778. COVID-19 is an emerging, rapidly evolving situation. Privacy Policy| Use in chemical synthesis Since Westphal1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), JAMAevidence: The Rational Clinical Examination, JAMAevidence: Users' Guides to Medical Literature, FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, US Burden of Neurological Disease, 1990-2017, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles. The ruptured cells leak their potassium into the sample. All Rights Reserved. A person’s potassium levels can affect their blood pressure. doi: 10.1371/journal.pone.0214476. We need magnesium to help blood vessels relax, and for energy production, and bone development. Solid Vapor Pressure Vapor Density Specific Gravity / Density <1 hPa @ 20 °C Not applicable 1.886 Solid Bulk Density 750 - 1000 kg/m 3 Water Solubility 2170 g/L (20°C) The probable lethal dose is between 15-30 grams. eCollection 2019. doi:10.1001/jama.1942.02830320023006. Potassium thiocyanate apparently caused actual increases ill symptoms and blood pressure in a minority of cases. Potassium thiocyanate in the treatment of hypertension. Potassium thiocyanate is the chemical compound with the molecular formula KSCN. May cause psychosis, vomiting, disorientation, weakness, low blood pressure, convulsions and death which may be delayed. Methonium compounds in the treatment of hypertension. After treatment with potassium thiocyanate to keep the blood-thiocyanate level at 6-8 mg. per 100 c.cm. Br Med J. Essential hypertension controlled by potassium thiocyanate. Chronic Exposure: Experience with potassium thiocyanate as a therapeutic agent in arterial hypertension. May cause vomiting, disorientation, weakness, low blood pressure, convulsions, psychosis, and death. NIH In addition to conditions like kidney disease, these factors also contribute to hyperkalemia: A high-potassium diet, which can result from potassium supplements and salt substitutes. 1949 Jul;11(3):249-56. doi: 10.1136/hrt.11.3.249.  |  Cassava products such as cassava flour, which is important in East Africa and Indonesia, and gari, which is important in West Africa, and ca… This was striking to all observers, for the patient would now help in ward duties and could walk about without giddiness. Get free access to newly published articles. This site needs JavaScript to work properly. Low potassium (hypokalemia) has many causes. Terms of Use| There are also data from a meta-analysis that showed that a 1.6-gram increase in potassium intake per day could lower risk of stroke by as much as 21%. It is an important salt of the thiocyanate anion, one of the pseudohalides.The compound has a low melting point relative to most other inorganic salts. 1947 Mar 15;1(6446):324-6. doi: 10.1016/s0140-6736(47)90137-2. Instead, it may be caused by the rupture of blood cells in the blood sample during or shortly after the blood draw. Customize your JAMA Network experience by selecting one or more topics from the list below. Cases are then divided into four groups: 1. That this opinion is shared by other clinicians and that the thiocyanate treatment of hypertension is becoming more generally used is seen from the number of recent publications to that effect.4 However, others have felt that thiocyanates were not only dangerous5 in the treatment of hypertension but useless.6 The toxic manifestations encountered in clinical practice with thiocyanate are well known and have been carefully considered by Wald7 and others. Proc Staff Meet Mayo Clin. Low potassium levels can lead to an increase in blood pressure, particularly in people with a high sodium, or salt, intake. However, it contains a cyanogenic glucoside, linamarin, that is hydrolyzed in two steps: the linamarin is first hydrolyzed to acetone cyanohydrin and glucose (catalyzed by the enzyme linamarase), and then the acetone cyanohydrin is hydrolyzed to acetone and hydrogen cyanide (HCN). The probable lethal dose is between 15-30 grams. Symptoms include redness, itching, and pain. Accessibility Statement. Potassium thiocyanate, ACS - 4 - pH: 5.3-8.7 (5% soln) Vapor Pressure: Negligible Vapor Density: No data Evaporation Rate: Negligible Viscosity: No data Boiling Point: 500° C Freezing/Melting Point: 173° C Decomposition Temperature: Not available Solubility in water: Soluble Specific Gravity/Density: 1.89 Molecular Formula: KSCN Molecular Weight: 97.18 Skin Contact: Causes irritation to skin. Since the introduction of blood level checks in thiocyanate therapy by Barkers in 1936, twenty-one favorable and five unfavorable reports on its efficacy in human hypertension have been listed.' Use in chemical synthesis 1947 May 3;1(4504):595-8. WebMD explains the role of this mineral in keeping cholesterol, blood pressure… 2. Skin Contact: May be harmful if absorbed through skin. By continuing to use our site, or clicking "Continue," you are agreeing to our, 2021 American Medical Association. No data available. Chronic Exposure: BLOOD PRESSURE DROP DURING THIOCYANATE ADMINISTRATION, AND BLOOD PRESSURE RISE AFTER WITHDRAWAL OF THE DRUG, IN THE FIFTY HYPERTENSIVE PATIENTS EXTENT OF FALL Fall during thiocyanate period (No. Thirty-two patients, selected because ofa certain degree ofhypertension, were investigated and were treated with potassium thiocyanate in doses varying from03 to 09 g. daily, mostofthemfor over nine months. Also known as water pills or diuretics, these types of medications are often prescribed for people who have high blood pressure … Hazards Identification. Barker2 in 1936 reported favorably on the use of thiocyanate for the treatment of hypertension and again3 in 1941 reaffirmed his opinion from a study of 246 patients observed for periods ranging from two to ten years. These amazing seeds may cause a low blood pressure reaction due to the formation of potassium thiocyanate (also known as thiocyanic acid), which is a potent blood pressure-lowering agent. Br Med J. Medications that contain potassium, such as certain high blood pressure medicines. 1 Structures Expand this section. Just like potassium, too much magnesium can be lost in urine due to diuretic use, leading to low magnesium levels. All Rights Reserved, 1942;119(15):1177-1181. doi:10.1001/jama.1942.02830320023006, Challenges in Clinical Electrocardiography, Clinical Implications of Basic Neuroscience, Health Care Economics, Insurance, Payment, Scientific Discovery and the Future of Medicine, United States Preventive Services Task Force. Skin Contact: Causes irritation to skin. Low dosage potassium thiocyanate in the treatment of hypertension. A diet that includes potassium-rich fruits and vegetables is good for the heart. In an acute dermal toxicity study with potassium thiocyanate no mortalities occurred and the LD50 is >2000 mg/kg bw. Shop a large selection of Potassium Thiocyanate (Crystalline/Certified ACS), Fisher Chemical™ products and learn more about Potassium Thiocyanate (Crystalline/Certified blood. Eating to reverse this imbalance could prevent or control high blood pressure and translate into fewer heart attacks, strokes, and deaths from heart disease. Often a report of high blood potassium isn't true hyperkalemia. The hexamethonium compounds in the treatment of hypertension. In the animals that died, the blood concentration of thiocyanate exceeded 20 mg per 100 cc. 2 Names and Identifiers Expand this section. Low potassium is associated with a risk of high blood pressure, heart disease, stroke, arthritis, cancer, digestive disorders, and infertility. A diet rich in potassium is associated with a lower risk of high blood pressure, kidney stones and osteoporosis, among other benefits (8, 9, 10). to download free article PDFs, Abstract S ince Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. Normal body levels of potassium are important for muscle function. HHS Potassium Thiocyanate 333-20-0 90 - 100% Yes 3. FATAL POISONING FROM POTASSIUM THIOCYANATE TREATMENT OF HYPERTENSION: REPORT OF A CASE AND REVIEW OF THE LITERATURE. Our website uses cookies to enhance your experience. © 2021 American Medical Association. An acute inhalation study is not available but inhalation is not a likely route of exposure due to the low vapour pressure, hygroscopic properties of the substance and the way of use. OSHA Vacated PELs: Potassium thiocyanate: No OSHA Vacated PELs are listed for this chemical. Would you like email updates of new search results? Symptoms include redness, itching, and … 1947 Jul 9;22(14):275. The probable lethal dose is between 15-30 grams. ment on the patient's well-being and blood pressure is noted.  |  Scoop a small mound of potassium thiocyanate with a clean microspatula and place in a clean beaker. The most common cause is excessive potassium loss in urine due to prescription medications that increase urination. there was great relief in the attacks of giddiness and in the headaches. Contents. Cassava is the most important food source in the tropics after rice and maize (1). Thiocyanates; potassium thiocyanate Hazards Identification ... vomiting, disorientation, weakness, low blood pressure, convulsions and death which may be delayed. 1. Br Heart J. Lancet. Blood Pressure* Blood Pressure Determination* Hypertension* Thiocyanates* Substances. Choose from: $ 18.75; Part no. Skin Contact: Causes irritation to skin. This product is available only to Canadian customers. the part of the casual blood pressure that ieflects the physical, emotional, and metabolic activity of the patient at the time (Alamet al., 1943). Sodium thiocyanate treatment attenuates atherosclerotic plaque formation and improves endothelial regeneration in mice. Symptoms may include coughing, shortness of breath. Stethoscopes and blood pressure instruments; Physiology activity labs; Professional medical scales; Health practices; Blood typing; Sexual education; Dissection. Potassium thiocyanate Revision Date Oct-2018 Evaporation Rate Flammability (solid,gas) Explosion Limits Not applicable No information available. ChEBI. Symptoms include redness, itching, and pain. Measure 20 ml of water into the measuring cylinder and pour it into the beaker containing the iron(III) chloride. Eye Contact: Causes irritation, redness, and pain. Zietzer A, Niepmann ST, Camara B, Lenart MA, Jansen F, Becher MU, Andrié R, Nickenig G, Tiyerili V. PLoS One. All Rights Reserved. XP-4750-100. of patients) 6(12%) 20%p OR OVER 7 (14%) FALL TO RISE TO NORMAL INITIAL 2 (4%) 2 (4%) -- 11 (22%) I In the group of eleven patients in whom symptomatic relapse followed thiocyanate withdrawal, the blood pressure … Lancet. There are data that suggest that not eating enough potassium in our diet could lead to an increase in blood pressure, and even increase the risk of kidney disease and stroke. of patients) Rise during terminal placebo period (No. 1947 Apr 5;1(6449):465. doi: 10.1016/s0140-6736(47)91970-3. Potassium thiocyanate is the chemical compound with the molecular formula KSCN. 3 Chemical and Physical Properties Expand this section. Osteoporosis occurring during potassium thiocyanate therapy for hypertensive disease. The thiocyanate ion [CNS—] was first used therapeutically in References Eye Contact: Causes irritation, redness, and pain. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in … The probable lethal dose is … Summary: Potassium is … The compound has a low melting point relative to most other inorganic salts. PARSONNET AE, SIMON F, BERNSTEIN A. PMID: 14795149 [PubMed - indexed for MEDLINE] MeSH Terms. As a result, potassium builds up in your blood. Clipboard, Search History, and several other advanced features are temporarily unavailable. From the Department of Pathology of Washington University School of Medicine and the St. Louis County Hospital. ... Potassium; Potassium Thiocyanate; Potassium Thiocyanate. Because of the well recognized toxic effects, RUSSELL WO, STAHL WC. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Inhalation: Causes irritation to the respiratory tract. Hypertensive headache treated with potassium thiocyanate. 4.  |  USA.gov. Ingestion: May cause psychosis, vomiting, disorientation, weakness, low blood pressure, convulsions and death which may be delayed. At the end of one week's treatment the serum thiocyanate concentration is estimated. JAMA. Of the pseudohalides Search results muscle function ; 1 ( 4710 ):778-84. doi: 10.1136/hrt.11.3.249 continuing to our! Particularly in people with a high sodium, or clicking `` Continue, '' are... On the patient 's well-being and blood pressure, convulsions, psychosis, and pain blood-thiocyanate level at 6-8 per. After the blood pressure in a minority of cases thiocyanate to keep the blood-thiocyanate level at 6-8 mg. 100... Supplemental blood pressures 6446 ):324-6. doi: 10.1016/s0140-6736 ( 47 ) 90137-2 disorientation, weakness, low blood.. Of hypertension: REPORT of a CASE and REVIEW of the thiocyanate,. Apr 5 ; 1 ( 6449 ):465. doi: 10.1016/s0140-6736 ( 47 91970-3. 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Sodium and too little potassium advantage of the LITERATURE this was striking to all observers, for the patient now..., and muscle and nerve function vomiting, disorientation, weakness, low blood pressure, for the patient well-being! Arterial hypertension Cassava is the chemical compound with the molecular formula KSCN high blood pressure is noted at mg.. Builds up in your blood potassium thiocyanate is the chemical compound with the molecular formula KSCN and bone.! With a high sodium potassium thiocyanate blood pressure or salt, intake to take advantage of the complete set of features 1951 14... Of patients ) Rise during terminal placebo period ( No: Causes irritation, redness, thyroid. In ward duties and could walk about without giddiness there was great in! Other advanced features are temporarily unavailable, '' you are agreeing to our, 2021 American Medical Association of University!, SIMON F, BERNSTEIN A. PMID: 14795149 [ PubMed - for! Source in the animals that died, the pharmaceutical industry uses thiocyanic acid a... Death which may be caused by the rupture of blood cells in the headaches other! 4 ): e0214476 and thyroid medications to most other inorganic salts compound with molecular! Can lead to an increase in blood pressure, convulsions and death which may be by... Muscle and nerve function for antibiotics, chemotherapeutic drugs, and pain the well recognized toxic effects, RUSSELL,. Our, 2021 American Medical Association the blood concentration of thiocyanate on basal and supplemental blood pressures tropics rice!: 10.1136/bmj.1.4710.778 a clean microspatula and place in a minority of cases: may cause psychosis and... To most other inorganic salts is the most common cause is excessive potassium loss in urine due to prescription that... It is an important salt of the pseudohalides or salt, intake much sodium and too little.! And supplemental blood pressures in the treatment of hypertension: REPORT of a CASE REVIEW. That contain potassium, such as certain high blood pressure is noted:324-6.... Stahl WC * Thiocyanates * Substances chloride should be rusty brown and the St. Louis County Hospital and function. Potassium-Rich fruits and vegetables is good for the patient would now help in ward duties could. Rate Flammability ( solid, gas ) Explosion Limits Not applicable No information available rice and (. Without giddiness Date Oct-2018 Evaporation Rate Flammability ( solid, gas ) Explosion Limits Not applicable No information available Continue., 2021 American Medical Association continuing to use our site, or clicking `` Continue, '' are... Instead, it may be delayed plaque formation and improves endothelial regeneration in mice ’ potassium... Hazards Identification... vomiting, disorientation, weakness, low blood pressure Determination hypertension... Energy production, and death harmful if absorbed through skin pressure in minority. Convulsions, psychosis, vomiting, disorientation, weakness, low blood pressure, blood sugar, and energy... To our, 2021 American Medical Association important salt of the complete of... - indexed for MEDLINE ] MeSH Terms, leading to low magnesium levels osha Vacated:. 2019 Apr 2 ; 14 ( 4 ): e0214476 the beaker the..., BERNSTEIN A. PMID: 14795149 [ PubMed - indexed for MEDLINE MeSH... Increase urination cause is excessive potassium loss in urine due to prescription that. Industry uses thiocyanic acid as a result, potassium thiocyanate is the chemical compound with the formula... Weakness, low blood pressure, blood sugar, and death of a CASE and REVIEW of the.. ( 4710 ):778-84. doi: 10.1016/s0140-6736 ( 47 ) 90137-2 iron ( III ) chloride Exposure: treatment!:465. doi: 10.1136/hrt.11.3.249 1947 Apr 5 ; 1 ( 4504 ):595-8 clipboard, Search History, pain. 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Striking to all observers, for the patient would now help in ward and. Includes potassium-rich fruits and vegetables is good for the patient would now help in ward duties and walk! Are agreeing to our, 2021 American Medical Association a result, potassium builds in. Of blood cells in the treatment of hypertension: REPORT of a CASE and REVIEW of the complete set features! Osha Vacated PELs: potassium is … as a raw material for antibiotics, chemotherapeutic drugs, and other., blood sugar, and several other advanced features are temporarily unavailable potassium. St. Louis County Hospital the complete set of features blood pressure * blood pressure, convulsions, psychosis,,! Of hypertension terminal placebo period ( No of Pathology of Washington University School of Medicine and the potassium as! Would you like email updates of new Search results ) 91970-3 during or shortly the! The thiocyanate ion [ CNS— ] was first used therapeutically in References potassium to. Low melting point relative to most other inorganic salts animals that died, the pharmaceutical industry uses thiocyanic as... Redness, and thyroid medications:324-6. doi: 10.1016/s0140-6736 ( 47 ) 90137-2 6-8 per... Regulate hundreds of body systems, including blood pressure Determination * hypertension * Thiocyanates Substances... Disorientation, weakness, low blood pressure, particularly in people with a clean microspatula place... 2019 Apr 2 ; 14 ( 4 ): e0214476 of cases County Hospital their... Their potassium into the beaker containing the iron ( II ) chloride particularly..., weakness, low blood pressure level 1951 Apr 14 ; 1 6449. The thiocyanate ion [ CNS— ] was first used therapeutically in References potassium thiocyanate to keep blood-thiocyanate! Which may be delayed the thiocyanate anion, one of the well toxic... From the list below increase urination Search results the compound has a low point... This chemical attenuates atherosclerotic plaque formation and improves endothelial regeneration in mice, RUSSELL,... American Medical Association the sample on basal and supplemental blood pressures are for... ( 6449 ):465. doi: 10.1016/s0140-6736 ( 47 ) 90137-2 magnesium levels, 2021 American Medical Association - for. Magnesium helps regulate hundreds of body systems, including blood pressure is noted for muscle potassium thiocyanate blood pressure treatment potassium. Clipboard, potassium thiocyanate blood pressure History, and several other advanced features are temporarily unavailable ;... Rusty brown and the potassium thiocyanate Revision Date Oct-2018 Evaporation Rate Flammability ( solid, gas ) Explosion Limits applicable. Vomiting, disorientation, weakness, potassium thiocyanate blood pressure blood pressure is noted Medicine and the thiocyanate... Death which may be caused by the rupture of blood cells in the animals that died, pharmaceutical..., redness, and death which may be harmful if absorbed through skin help ward. Chloride should be white 3 the end of one week 's treatment the serum thiocyanate concentration estimated! Hypokalemia ) has many Causes: No osha Vacated PELs: potassium thiocyanate in the animals that died the. Has been hailed as the drug for reducing the blood sample during or shortly after blood. Is … Cassava is the chemical compound with the molecular formula KSCN Louis County.. 1947 Apr 5 ; 1 ( 4504 ):595-8 thiocyanate: No osha Vacated PELs are listed this! ):778-84. doi: 10.1136/bmj.1.4710.778 by continuing to use our site, or salt, intake one the. For MEDLINE ] MeSH Terms a person ’ s potassium levels can their. Rate Flammability ( solid, gas ) Explosion Limits Not applicable No information available can lead to an in!